I'll never forget the nice buck that walked to the bottom of a small river bank as I was standing on top of an old farm bridge. I was 15 years old and it was the nicest buck I had ever seen as a young hunter. I was alone and I was already thinking about the stories I'd be telling.
I pulled up, took careful aim, fired, and watched my prize buck run away untouched. I could have cried. An important lesson was learned that day.
When you are presented with an uphill or downhill shot always aim low. There is some tricky math that can explain the reasons for this but forget the math and just remember to aim low in either situation.